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KMID : 0988920180160030409
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Intestinal Research
2018 Volume.16 No. 3 p.409 ~ p.415
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The association between new generation oral contraceptive pill and the development of inflammatory bowel diseases
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Sanagapalli Santosh
Ko Yanna
Kariyawasam Viraj
Ng Siew C
Tang Whitney
de Silva Hithanadura Janaka
Chen Minhu
Wu Kaichun
Aniwan Satimai
Ng Ka Kei
Ong David
Ouyang Qin
Hilmi Ida
Simadibrata Marcellus
Pisespongsa Pises
Gopikrishna Saranya
Leong Rupert W
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Abstract
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Background/Aims: To examine the association between use of oral contraceptive pills (OCPs) and the risk of developing inflammatory bowel diseases (IBD), in a modern cohort.
Methods: A prospective nested case-control study across sites in the Asia-Pacific region was conducted; involving female IBD cases and asymptomatic controls. Subjects completed a questionnaire addressing questions related to OCP use. Primary outcome was the risk of development of IBD of those exposed to OCP versus non-exposure. Secondary outcomes were development of Crohn’s disease (CD) versus ulcerative colitis (UC), and whether age of first use of OCP use may be associated with risk of IBD.
Results: Three hundred and forty-eight female IBD cases (41% CD, median age: 43 years) and 590 female age-matched controls were recruited. No significant association was found between OCP use and the risk of IBD (odds ratio [OR], 1.65; 95% confidence interval, 0.77?3.13; P=0.22), CD (OR, 1.55) or UC (OR, 1.01). The lack of association persisted when results were adjusted for age and smoking. IBD cases commenced OCP use at a younger age than controls (18 years vs. 20 years, P=0.049).
Conclusions: In this large cohort of subjects from the Asia-Pacific region, we found a modest but not significantly increased risk of developing IBD amongst OCP users.
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KEYWORD
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Inflammatory bowel diseases, Contraceptives, oral
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